Evaluation of Sysmex XN Series Optical Red Cell Parameters in Patients with Raised MCHC >36.5g/dL.

Time: 11:55 - 12:10

Date: 24 April 2018

Theatre: Dodder A


Increased Mean Corpuscular Haemoglobin Concentration (MCHC) >36.5g/dL can occur because of analytical interference or red cell disease. The aim of this study was to establish if optical red cell parameters RBC-O and HB-O from the Sysmex XN RET channel could be used to overcome raised MCHC’s caused by analytical interference. 299 unknown patient samples with MCHC >36.5g/dl were measured through the Sysmex XN RET channel.

RBC-O provided an accurate red cell count in cold agglutinin samples without the need for sample warming. In samples that had optical interference, HB-O was shown to provide an accurate HB count. Red cell disease group could be separated from all groups using an RBC score based on the reticulocyte count. An algorithm was determined using the optical parameters for routine use for samples with raised MCHC >36.5g/dL.


  • View full profile for Jane CulliganJane Culligan Senior Medical Scientist - Mater Misericordiae University Hospital

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